Because of the marked ability of LB-1.2 to sensitize xenografts of glioblastoma multiforme and neuroblastoma to TMZ, cancers also minimally inhibited by TMZ, [21] we studied the anti-tumor activity of LB1 (LB-1, LB-100), a water-soluble homolog of LB1.2 in combination with TMZ; each compound was also studied individually. The gene discussed is CKAP2; the disease is cancer.