ADGRL3 and familial pancreatic carcinoma: Offner et al. prepared polyclonal antibodies against extracellular domains of CL3 and CL4 [27], Ling et al. screened peptide types of CL4 binder by using a 12-mer peptide phage display library and CL4-expressing cells [28], Suzuki et al. generated a monoclonal antibody against the second extracellular loop of CL4 from mice immunized with a human pancreatic cancer cell line [29] and Romani et al. screened scFv against CL3 by using a human antibody phage display library [30].