Moreover, the physiological frequency of Fox-P3+ and Treg cells can suppress autoimmune disorders, but the reduction or even depletion of Fox-P3+ cells could lead to induction of autoimmunity by specific ablation of Treg cells in genetically targeted mice [45], these results indicated that the reduction of Treg cells probably enhanced the pathological process of AS. This evidence concerns the gene FOXP3 and autoimmune disease.