MAP2K3 and heart failure: Other key proteins in this network included: farnesyl-diphosphate faresyltranserferase 1 (Fdft1), also called squalene synthase, which increases intracellular cholesterol levels [32]; MAP2 kinase 3 (Map2k3) which has been shown to contribute to sex-based differences in myocardial remodelling and heart failure [33,34]; and the chemokine CXCL12 which regulates neutrophil and macrophage function (Figure 6, Table 3) [35].