Although the mechanisms responsible for the inflammatory response of tumour cells to reovirus infection have not been addressed to date, previous studies have implicated a role for NF-κB since i) reovirus infection initiates translocation of the p50/p65 NF-κB subunits to the nucleus and activates pro-apoptotic gene expression [32,44], ii) reovirus induces apoptosis in melanoma cells [7], and iii) NF-κB is involved in the production of chemokines and cytokines such as IL-8 and IFN-β [33]. This evidence concerns the gene CXCL8 and melanoma.