Hypothyroidism is associated with a worse cardiovascular risk factor profile including elevated cholesterol and low-density lipoprotein levels, diastolic hypertension, increased homocysteine and C-reactive protein concentrations, impaired thyroid hormone action on target tissue by smoking, tendency toward decreased fibrinolytic activity in mild and moderate hypothyroidism, and endothelial dysfunction with progression to atherosclerosis [43]. The gene discussed is TG; the disease is hypothyroidism.