Using the same experimental model of atopic asthma, it was further demonstrated that the brain and behavior changes observed in OVA-sensitized mice nasally challenged with OVA were (i) IgE dependent, being abrogated by anti-IgE treatment; (ii) mediated by mast cell degranulation, being blocked by the use of sodium cromoglicate (cromolyn, an inhibitor of mast cell degranulation); (iii) not related to airway inflammation, since sensitized C3H/HeJ mice, which did not present pulmonary inflammatory infiltrate, exhibited brain and behavioral changes similar to BALB/c animals [68]. The gene discussed is IGHE; the disease is atopic asthma.