In particular, it can occur—more often at the cytoplasmic level—in B-plasmablastic lymphomas bearing a distinctive phenotype (ALK+, CD138+, EMA+, IgA+/−, Bcl-2 protein+/−, CD4−/+, CD57−/+, CD20−, CD3−, and CD30−): like ALCL, these tumors do also carry cytogenetic abnormalities involving the ALK gene [38]. The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.