The nonradioactive Anti-dsDNA-NcX ELISA, which is based on dsDNA-loaded nucleosomes as antigens, demonstrated excellent test characteristics for the assessment of the diagnosis and disease activity that can be optimized even if clinicians interpret delivered test results within a medical context and consider the presence of drugs and infections having the potential to induce autoantibodies against dsDNA and/or nucleosomes. The gene discussed is TLX2; the disease is infection.