In cases of elevated anti-dsDNA titers, it is clinically relevant to exclude other causes, such as infection with Epstein-Barr virus or hepatitis B virus as well as the use of drugs such as hydralazine, tumor necrosis factor (TNF) inhibitors, interferons, sulfasalazine and many more to ensure the accurate diagnosis of SLE [5,6]. The gene discussed is TNF; the disease is systemic lupus erythematosus.