IDH1 and cancer: Affected cancer types include gliomas of intermediate malignant grade (73–94%) [1], [2] and acute myeloid leukemias (AMLs, 16–22%) [3], [4], [5], [6], and cases of IDH1 mutations have been reported in prostate cancer [7], acute lymphoblastic leukemia, B type [7], colorectal cancer [8], and melanoma [9].