TLX1 and acute lymphoblastic leukemia: For example, the t(10;14)(q24;q11) and t(7;10)(q35;q24) translocations in T-ALL juxtapose the TLX1 gene on chromosome 10 to T cell regulatory elements (either TCRδ in the t(10;14) or the TCRβ enhancer in the t(7;10) [10].