We have chosen the widely used NIH:OVCAR3 epithelial ovarian carcinoma cell line for our studies because, like most serous ovarian carcinomas, these cells overexpress CA125/MUC16 at the their surface and they show a complete epithelial phenotype (Hamilton et al, 1983; Yin and Lloyd, 2001; Rump et al, 2004). The gene discussed is MUC16; the disease is ovarian serous carcinoma.