CRP and obesity due to melanocortin 4 receptor deficiency: It is secreted primarily by the liver after its synthesis is triggered by pro-inflammatory cytokines such as interleukin-6, which is thought to be released by adipose tissue.2 Current evidence suggests that elevated blood levels of CRP are associated with older age, obesity, smoking, no or heavy alcohol intake, and a lower level of physical activity.6–10 Intakes of some nutrients or foods (eg, n-3 polyunsaturated fatty acids [n-3 PUFAs], fiber, vegetables, fruit, and fish) have also been reported to be associated with serum CRP concentration.11–14