There is a relationship between chronic inflammation and obesity [32], characterized by increased secretion of proinflammatory cytokines such as interleukin-(IL)-6, IL-8 and MCP-1/CCL2, abundant infiltration of activated macrophages into adipose tissue and obesity-induced insulin resistance [33]. The gene discussed is CXCL8; the disease is obesity due to melanocortin 4 receptor deficiency.