Patients with AOA1 present with cerebellar ataxia and oculomotor apraxia between ages 2 and 18 years old [2] accompanied later in life by limb dysmetria and sensory-motor neuropathy which may be associated with dystonia or mental retardation, hypoalbuminemia, hypercholesterolemia and normal immunoglobulins and alpha-fetoprotein levels. The gene discussed is AFP; the disease is Oculomotor apraxia.