TIMP1 and neoplasm: In addition to EMT twist has also other features which are linked to the growth or metastasis of tumor cells, i.e. it downregulates the expression of tissue inhibitors of metalloproteinase 1 (TIMP1) mRNA in Saos cells [30] promotes angiogenesis by inducing vascular endothelial growth factor (VEGF) and stimulates cancer cell migration [31,32].