LDLRAP1 and scrapie: Thus the overall results of the analysis concluded that an increase in the proportion of the ARR/AHQ, AHQ/VRQ, ARH/VRQ, ARQ/VRQ genotypes, in the proportion of NSP type V, or in the proportion of the ARH, ARQ, AHQ and VRQ alleles increased significantly the expected number of scrapie cases in affected holdings.