To test this hypothesis, we first examined the effects of expressing ASIC3 in brain on tests of innate fear and anxiety, including predator odor-evoked freezing, CO2-evoked freezing and open-field behavior, all of which are impaired by ASIC1a disruption (Coryell et al. 2007; Wemmie et al. 2003; Ziemann et al. 2009). The gene discussed is ASIC3; the disease is Anxiety.