Since the entire polyalanine tract of the COOH-terminus of FOXL2 is important for transcriptional repression of the steroidogenic acute regulatory (StAR) gene [22], either the FOXL2 deletion or mutation-dependent protein truncation before the polyalanine tract might increase StAR expression, thereby resulting in the development of POF. This evidence concerns the gene FOXL2 and premature menopause.