The present study showed that both adefovir as well as lamivudine brought about early normalization of serum ALT levels with reduction in serum and hepatic HBV DNA load, also reduction in the HAI and fibrosis scores in patients with chronic hepatitis B. But there was no complete clearance from liver, showing that liver still harboured infection, raising the possibility of re-activation. Here, GPT is linked to chronic hepatitis B virus infection.