The patient's medical history included renal cell carcinoma and nephrectomy, transurethral resection of the prostate for benign prostatic hyperplasia, and hypertension, He denied any use of non-steroidal anti-inflammatory drugs or angiotensin-converting enzyme (ACE) inhibitors, any history of urticaria or laryngeal edema, any drug allergies, or any family history of angioedema. This evidence concerns the gene ACE and hypertensive disorder.