Some of the HIF-1α targets involved in MDR and aggressive cancer involve MDR1, matrix metalloproteinases (MMP), vascular endothelial growth factor (VEGF), VEGF receptor, transforming growth factor (TGF)-α, cyclooxygenase (COX)-2, nitric oxide synthase (NOS), insulin-like growth factor (IGF)-2, cathepsin D (CATHD), collagen type V (α1) [21,22,24,26,28-32]. The gene discussed is ABCB1; the disease is cancer.