JAM3 and infection: In general, the analyzed tumor samples showed no characteristic pro-angiogenic signature, but revealed an significant up-regulation of genes (e.g. Stat1, Sell, Vcam1, Itgb2, F11r, Jam3, Cd47, Cd97, Sdc1, Sdc2, Sdc4) involved in leukocyte-endothelial cell interaction and recruitment of immune cells to sites of infection (Figure 3e).