HDGFL2 and infection: Biswas et al. (2005) studied HRP2 levels and antibody titres to HRP2 in 45 subjects in a low-transmission area for up to 6 weeks following infection with P. falciparum and found that HRP2 antigen remained elevated for at least 7 days post-treatment, despite the development of HRP2-specific immune responses. Our findings were thus consistent with the conclusions of Biswas et al., that antibody levels to HRP2 are unlikely to exert an important effect on test results in children with severe febrile illness.