It is also noteworthy that the control mice, even with severe hyperglycemia (∼400 mg/dL, Figure 1(f)), did not secrete more insulin to reduce high blood glucose levels (4 wk after STZ, 0.48 ng/mL, Figure 2(i)), indicating a very obvious deficit in insulin production and/or secretion in the control mice after STZ treatment. This evidence concerns the gene INS and Hyperglycemia.