The generation of high frequencies of functional antigen-specific CD8+ T cells against two tumor-associated antigens, as assessed by IFN-γ secretion, enumeration of tetramer-binding antigen-specific CD8+ T cells, and in vitro and in vivo cytotoxic assays prove archaeosomes as a highly effective adjuvant for breaking tolerance to tumor self-antigens. The gene discussed is IFNG; the disease is neoplasm.