The increased expression of the PPARδ target gene, Agptl4, the TGFβ-activated genes Runx1 and Runx2, and S100A8 and S100A9 in the gastric tumors indeed suggests a duality of function of both PPARδ and TGFβ signaling in gastric tumorigenesis. The gene discussed is RUNX1; the disease is gastric neoplasm.