This unique action profile enables individual tailoring of the timing of basal insulin action.(1) In a combination regimen with prandial insulin, insulin glargine provides equivalent levels of glycemic control and reduces the frequency of hypoglycemia when compared to NPH insulin.(2, 3, 4) There is only one adult and one pediatric study comparing the regimen of intensive basal insulin supplementation with once daily glargine administration at breakfast versus bedtime.(5, 6). Here, INS is linked to Hypoglycemia.