Polymorphisms in 3 nucleotide excision repair pathway genes (XPD [Lys751Gln], XPC [Lys939Gln], and XPG [Asp1104His]), the base excision repair XRCC1 (Arg399Gln), and double-strand break repair XRCC3 (Thr241Met) were studied in 200 HL patients and 220 matched controls. The gene discussed is XRCC3; the disease is Hodgkins lymphoma.