NFKB1 and Hodgkins lymphoma: Chang et al. have reported that regular use of aspirin reduces the risk of developing HL [210], and since aspirin inhibits the activation of the transcription factor nuclear factor-κB (NF-κB) via inhibition of IκB kinase β, an activator of NF-κB [211], they investigated whether SNPs in genes involved in nuclear factor-κB (NF-κB) activation and inhibition, other inflammatory pathways, and aspirin metabolism influence HL risk in 473 patients with cHL and 373 controls [212].