Nieters et al. have looked at SNPs in genes encoding the family of Toll-like receptors (TLRs), IL10 and IL10RA in 710 patients with various forms of lymphoma, and matched controls and found that the IL10RA Ser138Gly variant had a 50% protective effect against Hodgkin's lymphoma (HL) [208]. The gene discussed is IL10; the disease is Hodgkins lymphoma.