FOXO1 and endometrial cancer: Moreover, some of the sex hormone-regulated downstream targets and components of the Wnt/β-catenin signaling pathway have also been implicated in endometrial carcinogenesis: both FOXO1 and CDH1 (E-cadherin) expression is decreased in endometrial cancer and is induced by progesterone [38] [39] while Survivin (BIRC5) is expressed at high levels in endometrial cancer and upregulated by estradiol [40].