The efficacy of the dual NVP-BEZ235 in targeting Akt and mTOR pathways cells has been recently proven in WM cells, as well as in other IgM-secreting low-grade lymphoma cell lines, where the compound was able to specifically inhibit phosphorylation of Akt, and downstream GSK3α/β and ribosomal protein S6 in a dose dependent manner in the WM cells, together with inhibited phosphorylation of mTOR, as well as of the downstream targets p70S6 and 4EBP1. This evidence concerns the gene AKT1 and lymphoma.