The tumor specific PKM2 oscillatesbetween an active tetramer and a less active dimer, regulated by phosphotyrosinebinding, although the details of this regulation have yet to be deciphered [67,68].The decreased activity of the PKM dimer may result in shunting of upstream glycolyticintermediates into biosynthetic pathway, including lipid synthesis [68]. Here, PKM is linked to neoplasm.