Other orally dosed Akt inhibitors undergoing phase I first-in-human trials in cancer patients include GSK2141795 (GlaxoSmithKline, Brentford, UK), GSK2110183 (Octagon Research Solutions, Wayne, PA, US), GDC-0068 (Genentech, South San Francisco, CA, US), and LY2780301 (Eli Lilly and Company, Indianapolis, IN, US). Here, AKT1 is linked to cancer.