Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor; PDGF, platelet derived growth factor ; PDGFR, platelet derived growth factor receptor; PlGF, platelet derived growth factor; CRC, colorectal cancer; HBC, hepatobiliary cancers; HTN, hypertension; DVT, deep venous thrombosis; CHF, congestive heart failure; PE, pulmonary embolism; ALT, alanine transferase; HFS, hand-foot syndrome; LVEF, left ventricular ejection fraction. The gene discussed is VEGFA; the disease is Hand-foot syndrome.