The results obtained with S. Enteritidis were similar to those observed in S. Typhimurium - macrophages responded by a significantly higher transcription of GM-CSF, IL-1β, TNFα, IL-23α and IL-12β to the infection with the wild-type S. Enteritidis when compared with the non-infected PAMs and despite lower invasiveness, PAM infection with the S. Enteritidis ΔSPI1 mutant further significantly increased transcription of these genes (Table 3). The gene discussed is IL1B; the disease is infection.