Based on the macrophage phenotype classification in subclinical vs. clinical stages [38] and according to this and our previous studies [28], macrophages of SRLV asymptomatic sheep (such as the BMDM tested in this study) would exhibit increased B7 transcript production, whereas those of clinically affected sheep would be expected to have an increased MR expression and viral infection. Here, NR3C2 is linked to viral infectious disease.