APC and colonic neoplasm: In the present study, we determined the sensitivity of TMZ in the presence of NSC-124854 to several colon cancer cell lines (HCT-116, HCT-116-APC(KD), HCT-116+ch3, Caco-2, HT29, SW480, LoVo and RKO) using a clonogenic assay [18], [36], [46].