ATF5 and malignant glioma: Inhibition of other components of the ATF5-mediated survival pathway, including FGFR (using the specific inhibitor PD173074), EGFR (CL-387,785), RAS (manumycin A), MEK (U0126), ERK (FR180204) and PI3K (LY294002), also induces apoptosis in malignant glioma cells [11].