The increased expression of BIRC3 found in our analyses of LFS breast epithelial and stromal cells, and the normalization of expression with TP53 conformational rescue drugs, are consistent with an important role for BIRC3 anti-apoptotic signals in LFS initiated cells, and with recent findings that BIRC3 can drive tumorigenesis on a p53-deficient background in mouse osteosarcoma [36]. This evidence concerns the gene TP53 and osteosarcoma.