BMP4 and malignant colon neoplasm: Also induction of differentiation in colon CSCs by exposing these cells to Bone Morphogenetic Protein 4 (BMP4), which can initiate a differentiation program as well as mediate apoptosis [81], sensitizes colon cancer cells to killing with 5-FU or oxilaplatin in vivo, resulting in complete and long term regression of colon xenografts [82].