It is well documented that microglia have been recognized as gatekeepers of CNS diseases and immunology [39] and that microglial cells activated by LPS, by hypoxia, or by neurodegenerative diseases produce increased amounts of proinflammatory cytokines such as TNF-α and IL-1β in the CNS [40-43]. The gene discussed is IL1B; the disease is neurodegenerative disease.