Another study extended these findings, reporting that CRSwNP had Th2 polarization and a higher prevalence of IL-5, IgE, eosinophils, eotaxin, and eosinophil cationic protein, whereas CRSsNP had Th1 polarization and higher levels of interferon-gamma and transforming growth factor (TGF)-beta [147]. The gene discussed is IGHE; the disease is chronic rhinosinusitis without nasal polyps.