Similar to cells treated with control siRNA, cell-associated levels of CD317 were still drastically reduced upon depletion of β-TrCP1 in the majority of HIV-1 wt-infected cells (80 ± 2% p24CA+CD317- cells versus 15 ± 3% p24CA+CD317- cells for HIV-1Δvpu infection; Figure 8B,C). The gene discussed is BST2; the disease is infection.