In addition, mitral valve prolapse may also be observed.16 Aortic root dilation was found in 60% of a series of patients with Marfan's syndrome (74% males, 33% females) while mitral valve prolapse was found in 91% (87% males, 100% females).13 The histopathology of the aortic wall is characterized by widespread fragmentation of the elastin component, and the elastin fibers are often thin. This evidence concerns the gene ELN and mitral valve disorder.