Although having been overlooked in the GD research field for more than a decade, HLA-DPB1*05:01 was shown to be associated with several other immune-related phenotypes/diseases such as multiple sclerosis [37], primary biliary cirrhosis [38] and chronic hepatitis B infection [39], which, to some degree, supports that DPB1*05:01 is an HLA allele with pertinent biological significance. The gene discussed is HLA-DPB1; the disease is primary biliary cholangitis.