While a role for PRKD2 (Protein Kinase D2) in CLL is limited, low levels of PRKD2 expression and autophosphorylation have been reported to be a feature of a number of B-cell tumors including mantle cell and Burkitt's lymphoma, and ~50% of CLL/small lymphocytic lymphomas [19]. This evidence concerns the gene PRKD2 and B-cell chronic lymphocytic leukemia.