Future studies to address the functional consequences of an anti-BLyS response are of interest [28], wherein we would evaluate the ability of multiple immunizations with PsaA-BLyS to attenuate disease progression and autoantibody production in an MRL/lpr mouse model of SLE or in a collagen induced arthritis mouse model of RA [29,30]. Here, TNFSF13B is linked to rheumatoid arthritis.