There was no significant correlation between SIAH2 expression and nuclear grade, presence of necrosis, age, ER, progesterone receptor (PR), EGFR or HER2 (all P > 0.05) or intrinsic phenotypes in DCIS (P = 0.471) (Supplementary Table 3 in Additional file 3). The gene discussed is ESR1; the disease is ductal breast carcinoma in situ.