SIAH2 and breast neoplasm: The absence of a positive correlation with ER is of interest, since estrogen has been reported to induce expression of SIAH2 in ER-positive breast cancer cell lines [19] and there is a positive relationship between Siah2 and ER-positive breast tumors but not the basal-like phenotype in six publicly accessible data sets [7,20-25] (analysis not shown).