SIAH2 and neoplasm: The significant associations between SIAH2 expression grade and intrinsic subgroups were confirmed in a multivariate analysis of tumor phenotype, age, grade and lymph node status with the basal-like phenotype being more than five times more likely to express SIAH2 than luminal tumors (Table 3) (P = 0.015), which was also observed in the combined cohort (P = 0.042).