In the combined cohort, there was a significant inverse correlation between SIAH2 and ER (P < 0.0001) and PR (P < 0.0001) and a positive correlation with tumor grade (P < 0.0001), HER2 (P = 0.007), p53 (P < 0.001) and intrinsic subtype (P < 0.0001), but not with patient age, tumor size or lymph node status (P > 0.05) (Table 2). The gene discussed is ESR1; the disease is neoplasm.