ACE and Alzheimer disease: A report using 3xTg-AD mice (∼3 months of age) and APPSw/Ind mice (16–17 months) indicated that blood flow insufficiency should be prolonged enough to accelerate AD pathology; here, the use of captopril (a commonly used anti-hypertensive drug) and resultant modest inhibition (∼30%) of brain angiotensin-converting enzyme (Aβ-degrading) activity for 28 days did not affect Aβ catabolism [37].