It should be noted that it is not the first time that we observe increased CaMKII activation not correlating with increased tau phosphorylation in vivo; for example, 10 days of diabetes induced by streptozotocin resulted in more than 1000% increase in p-CaMKII but no detectable phosphorylation at either pS262 or pS356, two sites demonstrated to be phosphorylated by CaMKII in vitro[48]. This evidence concerns the gene MAPT and diabetes mellitus.